邮箱：lukuangda@bjmu.edu.cn

地址：北京市海淀区学院路38号

个人简介

2011年毕业于北京大学，获学士学位；2016年毕业于芝加哥大学，获博士学位；2016-2018年在芝加哥大学肿瘤放射中心与化学系从事博士后工作。现为北京大学临床医学高等研究院跨学部生物医学工程系副研究员、博士生导师。研究聚焦于新型放射、光动力增敏纳米材料的开发与应用，特别是设计开发肿瘤放射动力治疗纳米材料，相关产品已在美国进入临床II期人体试验。曾荣获American Chemical Society Young Investigator Award (Division of Inorganic Chemistry), American Chemical Society Yao Yuan Award of Medicinal Chemistry (Second Place)等荣誉。获得国家自然科学基金区域联合基金、国家自然科学基金青年基金，北京大学临床医学+X项目等资助。在Nature Biomedical Engineering，Journal of American Chemical Society , Advanced Materials等期刊发表多篇代表工作。

主要研究方向

(1) 基于纳米复合材料的新型肿瘤放射治疗方法及其机理研究；

(2) 基于纳米材料的肿瘤联合治疗，包括化学疗法、光动力疗法、放射疗法、基因疗法、免疫疗法等；

(3) 肿瘤诊疗一体纳米材料开发

代表性科研项目

X射线与乏氧激活的金铜纳米材料诱导铜死亡协同头颈癌放射治疗，北京大学临床医学+X青年专项

线粒体靶向光动力/放射动力增敏纳米材料用于乏氧头颈癌治疗，北京大学临床医学+X青年专项

基于空间构型与生物学特性以PSMA为靶点的68Ga/177Lu诊疗一体化核药研究， 国家自然科学基金区域联合项目

短双歧杆菌负载金属有机骨架材料用于乏氧肿瘤的光动力治疗，国家自然科学基金青年项目

10篇代表性论文

1. Lu, K.; He, C.; Guo, N.; Chan, C.; Ni, K.; Lan, G.; Tang, H.; Pelizzari, C.; Fu, Y.-X.; Weichselbaum, R. R.; Lin, W. Low-dose X-ray Radiotherapy-Radiodynamic Therapy via Nanoscale Metal-Organic Frameworks Enhances Checkpoint Blockade Immunotherapy. Nat. Biomed. Eng. 2018, 2, 600-610

2. Lu, K.; Aung, T.; Guo, N.; Weichselbaum, R. R.; Lin, W. Nanoscale Metal-Organic Frameworks for Therapeutic, Imaging, and Sensing Applications. Adv. Mater. 2018, 30 (37), 1707634

3. Lu, K.; He, C.; Guo, N.; Chan, C.; Ni, K.; Weichselbaum, R. R.; Lin, W. Chlorin-Based Nanoscale Metal−Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy. J. Am. Chem. Soc. 2016, 138 (38), 12502-12510

4. Lu, K.; He, C.; Lin, W. A Chlorin-Based Nanoscale Metal−Organic Framework for Photodynamic Therapy of Colon Cancers. J. Am. Chem. Soc. 2015, 137 (24), 7600-7603

5. Lu, K.; He, C.; Lin, W. Nanoscale Metal–Organic Framework for Highly Effective Photodynamic Therapy of Resistant Head and Neck Cancer. J. Am. Chem. Soc. 2014, 136 (48), 16712-16715

6. He, C.#; Lu, K.#; Lin, W. Nanoscale Metal–Organic Frameworks for Real-Time Intracellular pH Sensing in Live Cells. J. Am. Chem. Soc. 2014, 136 (35), 12253-12256 (Co-First Author)

7. Li, J.; You, Z.; Zhai, S.; Zhao, J.; Lu, K. Mitochondria-Targeted Nanosystem Enhances Radio-Radiodynamic-Chemodynamic Therapy on Triple Negative Breast Cancer. ACS Appl. Mater. Interfaces 2023, 15, 21941-21952

8. Li, J.; You, Z.; Zhai, S.; Zhao, J.; Lu, K. Au−ZnO Nanomatches as Radiosensitizers with Improved Reactive Oxygen Species Generation and Tumor Hypoxia Modulation for Enhanced Radiotherapy on Triple-Negative Breast Cancer. ACS Appl. Nano Mater. 2023, 6(18), 16362–16372

9. He, C.; Lu, K.; Liu, D.; Lin, W. Nanoscale Metal–Organic Frameworks for the Co-Delivery of Cisplatin and Pooled siRNAs to Enhance Therapeutic Efficacy in Drug-Resistant Ovarian Cancer Cells. J. Am. Chem. Soc. 2014, 136 (14), 5181-5184

10. Xu, R.; Wang, Y.; Duan, X.; Lu, K.; Micheroni, D.; Hu, A.; Lin, W. Nanoscale Metal–Organic Frameworks for Ratiometric Oxygen Sensing in Live Cells. J. Am. Chem. Soc. 2016, 138(7), 2158-2161