邮箱：jie.qiao@263.net

地址：北京市海淀区学院路38号

个人简介：

乔杰，政协第十四届全国委员会委员。现任北京大学党委常委，常务副校长、医学部主任，女性生育力促进全国重点实验室主任。乔杰教授是我国自主培养的生殖医学领军人物，立足学科领域前沿，持续攻坚克难，长期致力于从事妇产及生殖健康相关临床、基础研究与转化工作，并持续关注妇幼公共卫生体系建设，守护妇儿全生命周期健康。以第一和通讯作者（含共同）在Cell、Nature、Science、JAMA、Lancet等高水平杂志发表700余项研究成果。

主要研究方向：

带领团队聚焦遗传机制解析人类生殖细胞转录组、甲基化组、蛋白组等分子特征，绘制分子水平发育图谱，拓展生育力维持机制的认知边界；针对卵成熟障碍问题研发系列新型冷冻保存技术及产品，提高卵泡及卵母细胞存活率并实现转化，提升了生殖医学领域相关产品国产制剂自主研发占比。围绕配子胚胎发育基础研究：建立了世界首张人类女性卵子高精度全基因组测序图谱，揭示了人卵子染色体重组规律，为遗传病连锁分析奠定了理论基础；解析了人类生殖系统从原始生殖细胞到成熟精、卵的转录组、甲基化组等分子特征，描绘出正常生理情况下人类生殖系细胞发育历程；构建了人类胚胎早期发育过程调控网络，阐释了从受精到围着床期人类胚胎早期发育过程基因转录与表观遗传调控，揭示了滋养层细胞分化障碍是导致人类胚胎着床失败原因。

 

代表性科研项目：

1、国家自然科学基金卓越研究群体项目（原基础科学中心项目）（82288102） 女性生殖衰老与生育力重塑

2、国家重点研发计划（2019YFA0801401）囊胚细胞的编程和重编程机制

10篇代表性论文：

1. Zhou, S., Li, M., Wang, P., Guo, C., Zhang, J., Luo, X., Fan, Y. C., Chen, E. Q., Qi, X., Chen, J., Ye, L., Yuan, H. Y., Yin, W. B., Wang, K., Zheng, M. H., Pang, Y., Qiao, J*., & Jiang, C. (2025). A symbiotic filamentous gut fungus ameliorates MASH via a secondary metabolite-CerS6-ceramide axis. Science (New York, N.Y.), 388(6746), eadp5540.

2. Lu, Y., Qin, M., He, Q., Hua, L., Qi, X., Yang, M., Guo, Q., Liu, X., Zhang, Z., Xu, F., Ding, L., Wu, Y., Zhang, C., Zhai, F., Liu, Q., Li, J., Yuan, P., Shi, X., Wang, X., Zhao, C., … Qiao, J*. (2024). How the extra X chromosome impairs the development of male fetal germ cells. Nature, 10.1038/s41586-024-08104-6.

3. Wang, Y., Li, R., Yang, R., Zheng, D., Zeng, L., Lian, Y., Zhu, Y., Zhao, J., Liang, X., Li, W., Liu, J., Tang, L., Cao, Y., Hao, G., Wang, H., Zhang, H., Wang, R., Mol, B. W., Huang, H., & Qiao, J*. (2024). Intracytoplasmic sperm injection versus conventional in-vitro fertilisation for couples with infertility with non-severe male factor: a multicentre, open-label, randomised controlled trial. Lancet (London, England), 403(10430), 924–934.

4. Nie, Q., Luo, X., Wang, K., Ding, Y., Jia, S., Zhao, Q., Li, M., Zhang, J., Zhuo, Y., Lin, J., Guo, C., Zhang, Z., Liu, H., Zeng, G., You, J., Sun, L., Lu, H., Ma, M., Jia, Y., Zheng, M. H., … Qiao, J*&Jiang, C. (2024). Gut symbionts alleviate MASH through a secondary bile acid biosynthetic pathway. Cell, S0092-8674(24)00350-7. Advance online publication.

5. Qiao, J*#. , Wang, Y. Y. , Kong, F. , & Fu, Y.(2023).Medical education reforms in China. Lancet, 401(10371): 103-104.

6. Wang, K. , Zhang, Z. W. , Hang, J. , Liu, J. , Guo, F. S. , Ding, Y. , Li, M. , Nie, Q. X. , Lin, J. , Zhuo, Y. Y. , Sun, L. L. , Luo, X. , Zhong, Q. H. , Ye, C. , Yun, C. Y. , Zhang, Y. , Wang, J. , Bao, R. , Pang, Y. L. , Wang, G. , Gonzalez, F. J. , Lei, X. G. , Qiao, J*. , & Jiang, C. T. (2023).Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target. Science, 381(6657): 501.

7. Dang, Y. J. , Zhu, L. , Yuan, P. , Liu, Q. , Guo, Q. Y. , Chen, X. , Gao, S. X. , Liu, X. , Ji, S. S. , Yuan, Y. F. , Lian, Y. , Li, R. , Yan, L. Y. , Wong, C. , & Qiao, J*.(2023). Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution. Cell Discovery, 9(1).

8. Qiao J*, Wang Y, Li X, Jiang F, Zhang Y, Ma J, Song Y, Ma J, Fu W, Pang R, Zhu Z, Zhang J, Qian X, Wang L, Wu J, Chang HM, Leung P, Mao M, Ma D, Guo Y, Qiu J, Liu L, Wang H, Norman RJ, Lawn J, Black RE, Ronsmans C, Patton G, Zhu J*, Song L*, Hesketh T.(2021). A Lancet Commission on 70 years of women's reproductive, maternal, newborn, child, and adolescent health in China. Lancet.397(10293):2497-2536.

9. Chen L, Li Q, Zheng D, Jiang H, Wei Y, Zou L, Feng L, Xiong G, Sun G, Wang H, Zhao Y*, Qiao J*. (2020).Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. New Engl J Med.382:e100.

Qiao J*.(2020). What are the risks of COVID-19 infection in pregnant women? The Lancet.395:760-762.