地址：北京市海淀区学院路38号

邮箱：wang-jc@bjmu.edu.cn

个人简介：

王坚成教授，北京大学博雅特聘教授，药学院药剂学系博士生导师，教育部长江学者特聘教授，科技部科技创新中青年领军人才。现任药学院党委委员，北京大学科研部副部长兼医学部科研处处长，北京大学宁波海洋药物研究院副院长，中国药学会核酸药物专委会副主任委员，中国药学会药剂专业委员会委员，北京药学会药剂专业委员会主任委员。曾担任《中华医学百科全书药剂学分卷》副主编，主编《现代药剂学》、《纳米粒药物输送系统》。主要研究领域有：分子药剂学、生物大分子药物（蛋白多肽和siRNA）体内给药系统及靶向性纳米药物递送系统研究。

代表性科研项目：

1. 利用精准药物递送体系增强化疗联合免疫治疗新策略对食管癌疗效的研究 京津冀基础研究合作专项项目J200018

2. 新型载体调控肠粘膜转运提高蛋白多肽口服生物利用度的分子机制研究 国家自然科学基金区域创新发展联合基金重点项目U22A20384

3. 索马鲁肽口服高效递释系统 宁波市重大科技任务攻关

4. mRNA药物开发及靶向递释技术平台建设 国家重点研发计划项目2023YFC3403100

5. 人工智能（ AI）辅助的脂质纳米颗粒(LNP)关键质量属性指标及其体内命运研究 北京市自然科学基金-海淀原始创新联合基金

10篇代表性论文：

1. Shi-He Cui,# Yi Yan,# An Lu,# Yun Dou, Zhen-Wen Li, Ze-Hang Zhu, Ming-Ze Du, Yue-Feng Zhu, Xin Chen, Xiangyu Wang, Lin-Xia Jiang, Yujie Shi, Xiaoyan Liu, Yuan-jun Zhu,* Dong Jiang,* and Jian-Cheng Wang*,Nanomedicines Promote Cartilage Regeneration in Osteoarthritis by Synergistically Enhancing Chondrogenesis of Mesenchymal Stem Cells and Regulating Inflammatory Environment. ACS Nano 2024, 18, 8125−8142

2. An Lu, Zhiyi Xu, Zhixia Zhao, Yi Yan, Linxia Jiang, Jing Geng, Hongwei Jin, Xiangyu Wang,Xiaoyan Liu, Yuanjun Zhu, Yujie Shi, Lihong Liu, Huaping Dai,* and Jian-Cheng Wang*，Double Braking Effects of Nanomedicine on Mitochondrial Permeability Transition Pore for Treating Idiopathic Pulmonary Fibrosis，Adv. Sci. 2024, 2405406

3. Xiang-Yu Wang, Yi Yan, Xiao-Ru Guo, An Lu, Lin-Xia Jiang, Yuan-Jun Zhu, Yu-Jie Shi,Xiao-Yan Liu, and Jian-Cheng Wang*，Enhanced Tumor Immunotherapy by Triple Amplification Effects of Nanomedicine on the STING Signaling Pathway in Dendritic Cells，Adv. Healthcare Mater. 2024, 2403143

4. Yi Yan, An Lu, Yun Dou, Zhen Zhang, Xiang-Yu Wang, Lin Zhai, Li-Ya Ai, Ming-Ze Du, Lin-Xia Jiang, Yuan-Jun Zhu, Yu-Jie Shi, Xiao-Yan Liu, Dong Jiang,* and Jian-Cheng Wang*，Nanomedicines Reprogram Synovial Macrophages by Scavenging Nitric Oxide and Silencing CA9 in Progressive Osteoarthritis. Adv. Sci. 2023,10(11):2207490

5. Yi Yan, Xiao-Yu Liu, An Lu, Xiang-Yu Wang, Lin-Xia Jiang , Jian-Cheng Wang*,Non-viral vectors for RNA delivery， Journal of Controlled Release 342 (2022) 241–279

6. Smart drug delivery systems for precise cancer therapy, Xiaoyou Wang, Chong Li*, Yiguang Wang, Huabing Chen,Xinxin Zhang, Cong Luo, Wenhu Zhou, Lili Li, Lesheng Teng, Haijun Yu, Jiancheng Wang*,Acta Pharm Sin B 2022;12(11):4098-4121,

7. Yuanjun Zhu, Hu-Hu Han, Lin Zhai, Yi Yan, Xiaoyan Liu, Yinye Wang，Liandi Lei, Jian-Cheng Wang*, Engineering a “three-in-one” hirudin prodrug to reduce bleeding risk: A proof-of-concept study， Journal of Controlled Release 338 (2021) 462–471

8. Yi Yan, Cheng-Han Wang, Shi-He Cui, Lin Zhai, Jing Sun, Xiao-Yu Liu, Xin Chen,Yi Sun, Hong-Gang Qian, Xiang Gao, Yi-Da Tang, Yuan-Jun Zhu, Yu-Jie Shi,Qiang Zhang, Jian-Cheng Wang*, Enhanced cancer therapeutic efficiency of NO combined with siRNA by caspase-3 responsive polymers， Journal of Controlled Release 339 (2021) 506–520.

9. Chong Qiu#, Hu-Hu Han, Jing Sun, Hai-Tao Zhang, Wei Wei, Shi-He Cui, Xin Chen ,Jian-Cheng Wang* & Qiang Zhang，Regulating intracellular fate of siRNA by endoplasmic reticulum membrane-decorated hybrid nanoplexes， Nature Communication, 2019, Jun 20;10(1):2702.

10. Hai-Tao Zhang#, Jing Sun#, Yi Yan#, Shi-He Cui, Hao Wang, Cheng-Han Wang, Chong Qiu, Xin Chen, Jin-Song Ding, Hong-Gang Qian, Jian-Cheng Wang⁎, Qiang Zhang，Encapsulated microRNA by gemcitabine prodrug for cancer treatment，Journal of Controlled Release，2019，316:317–330