邮箱：kcquan@pku.edu.cn

地址：北京市海淀区学院路30号天工大厦C座

个人简介：

工作及教育背景：

2024.06-至今 北京大学第三医院 副研究员

2021.12-2024.06 北京大学 博士后 （合作导师郑玉峰）

2016.11-2021.06 格罗宁根大学 博士 （导师Henk J Busscher）

奖项：

博士后国际交流计划引进项目（资助编号：YJ20220029）

北京大学博雅博士后项目

学术兼职：

Microorganisms杂志客座编辑 (Special issue: Bacterial Biofilm Microenvironments: Their Interactions and Functions)

主要研究方向：

研究方向一：磁响应复合涂层及其抗菌、成骨机制

• 针对骨外科植入物细菌感染导致成骨效果不佳问题，利用磁驱动力，物理破坏细菌生物被膜结构，增强抗生素治疗效率。

• 开发环境响应型复合涂层，兼顾磁性材料的磁可控性及涂层结合力，同时促进骨整合。

研究方向二：磁性纳米抗菌材料

• 针对细菌耐药问题，开发磁性纳米材料，利用磁驱动力物理破坏细菌细胞膜，杀死细菌的同时不产生耐药性

代表性科研项目：

• 国家自然科学基金委员会, 青年科学基金项目（C类）[原青年科学基金项目], 52201293, “磁驱动”抗菌涂层的设计制备及机制研究, 2023-01-01 至 2025-12-31, 30万元, 在研, 主持

• 中国博士后科学基金会, 中国博士后科学基金第71批面上资助二等, 2022M710189, "磁响应”抗菌涂层的制备及性能研究, 2022-06 至 2024-06, 8万元, 结题, 主持

10篇代表性论文：

1. Kecheng Quan, Yupu Lu, Ting Zhang, Shuren Wang, Hao Tang, Chunhao Yu, Yongsheng Zhou, Yunsong Liu*, Dandan Xia* and Yufeng Zheng*, Magnetically-Drivable, pH-Responsive Fe₃O₄/ZIF-8 Coating on Implant for Biofilm Prevention and Treatment, Nano Today 2025, 64:102772. (JCR Q1, IF: 13.2)

2. Kecheng Quan, Zhinan Mao, Yupu Lu, Yu Qin, Shuren Wang, Chunhao Yu, Xuewei Bi, Hao Tang, Xiaoxiang Ren, Dafu Chen, Yan Cheng, Yong Wang, Yufeng Zheng, Dandan Xia , Composited silk fibroins ensured adhesion stability and magnetic controllability of Fe₃O₄-nanoparticle coating on implant for biofilm treatment, Materials Horizons 2024, 44(13): 3157-3165. (JCR Q1, IF: 12.2)

3. Kecheng Quan, Yupu Lu, Zhinan Mao, Shuren Wang, Xiaoxiang Ren, Chunhao Yu, Ting Zhang, Jing-Jun Nie, Yan Cheng, Dafu Chen, Yufeng Zheng, Dandan Xia , Functionalized-nanoparticles/silk fibroin coating with anti-adhesive and photothermal capabilities to prevent implant-associated infections, Chemical Engineering Journal 2024, 486: 150147. (JCR Q1, IF: 15.1)

4. Kecheng Quan, Yu Qin, Kai Chen, Miaomiao Liu, Xiaoliang Zhang, Peng Liu, Henny C. van der Mei, Henk J. Busscher, Zexin Zhang, Lethal puncturing of planktonic Gram-positive and Gram-negative bacteria by magnetically-rotated silica hexapods, Journal of Colloid and Interface Science 2024, 664: 275-283. (JCR Q1, IF: 9.9)

5. Kecheng Quan, Jiapeng Hou, Zexin Zhang*, Yijin Ren, Brandon W. Peterson, Hans-Curt Flemming, Christian Mayer, Henk J. Busscher, Henny C. van der Mei*, Water in bacterial biofilms: pores and channels, storage and transport functions. Critical Reviews in Microbiology 2022, 48: 283-302. (JCR Q1, IF: 6.0)

6. Kecheng Quan, Zexin Zhang, Yijin Ren, Henk J. Busscher, Henny C. van der Mei, Brandon W. Peterson , On-demand pulling-off of magnetic nanoparticles from biomaterial surfaces through implant-associated infectious biofilms for enhanced antibiotic efficacy, Materials Science & Engineering C 2021, 131: 112526. (JCR Q1, IF: 8.1)

7. Kecheng Quan, Zexin Zhang*, Yijin Ren, Henk J. Busscher*, Henny C. van der Mei*, Brandon W. Peterson, Possibilities and impossibilities of magnetic nanoparticle use in the control of infectious biofilms. Journal of Materials Science & Technology 2021, 69: 69-78. (JCR Q1, IF: 11.2)

8. Kecheng Quan, Guimei Jiang, Jian Liu, Zexin Zhang*, Yijin Ren, Henk J. Busscher*, Henny C. van der Mei, Brandon W. Peterson*, Influence of interaction between surface-modified magnetic nanoparticles with infectious biofilm components in artificial channel digging and biofilm eradication by antibiotics in vitro and in vivo. Nanoscale 2021, 13: 4644-4653. (JCR Q1, IF: 5.8)

9. Kecheng Quan, Zexin Zhang*, Yijin Ren, Henk J. Busscher*, Henny C. van der Mei and Brandon W. Peterson*, Homogeneous Distribution of Magnetic, Antimicrobial-Carrying Nanoparticles through an Infectious Biofilm Enhances Biofilm-Killing Efficacy. ACS Biomaterials Science & Engineering 2020, 6: 205-212. (JCR Q2, IF: 5.5)

10. Kecheng Quan, Zexin Zhang*, Hong Chen, Xiaoxiang Ren, Yijin Ren, Brandon W. Peterson, Henny C. van der Mei, Henk J. Busscher, Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics, Small 2019, 15(39): 1902313. (JCR Q1, IF: 13.0)