邮箱：zhangxulove@pku.edu.cn

地址：北京市昌平区北京大学新燕园校区

个人简介

张旭博士2016年在中国农业大学获得学士学位，2021年在清华大学获得博士学位，2021-2023年在清华大学化学工程系从事博士后研究，现为北京大学口腔医（学）院副研究员、博士生导师。主要从事口腔微环境精准调控与智能维护新技术研究。主持国家重点研发计划“增材制造与激光制造”重点专项课题、海南省卫生健康科技创新联合项目（重点项目）等项目。北京市科协“青年托举人才”，任Cell Proliferation、Exploration等学术期刊青年编委。

主要研究方向

        1. 生物3D打印与口腔微生理/病理模型构建

        2. 新型种植体开发及再生修复应用

        3. 口腔智能清洁系统开发

代表性科研项目

1. 国家重点研发计划课题，仿生病理微环境器官芯片高通量构建与评价，2024.12-2027.11，140万

2. 海南省卫生健康科技创新联合项目重点项目，取向压电生物聚酯复合支架负载功能聚酯颗粒协同促进脊髓损伤修复的研究，2025.3-2028.2，80万

10篇代表性论文

1. Jiang, S., Zhang, X.*, Chen, F., Zhao, Z., Zhang, C., Sun, Y*. Ketone body 3-hydroxybutyrate mitigates apoptosis and enhances osteogenesis in bone organoid construction via the cAMP/PKA/CREB signaling pathway. The FASEB Journal, 2025, 39, e70510. (*corresponding author)

2. Wang, F.#, Wu, Y.#, Zheng, F.#, Zeng, Y., Zhao, Z., Huang, Y., Zhang, X.*, Sun, B.*, Sun, Y*. A lasting antibacterial, pro-angiogenic, and pro-osteogenic zirconium-based bulk metallic glass for dental implants. View, 2025, 6, 20240099. (*corresponding author)

3. Zhou, P., Xie, Y., Meng, Y., Chen, Y., Xu, Z., Hua, H.*, Zhang, X*. ScRNA-Seq analysis of tongue tissues in chronic hyperplastic Candidiasis. Journal of Dental Research, 2025, 104, 64-74. (*corresponding author)

4. Li, J.#, *, Zhang, X.#, *, Peng, Z. X.#, Chen, J. H., Liang, J. H., Ke, L. Q., Huang, D., Cheng, W. X., Lin, S., Li, G., Hou, R., Zhong, W. Z., Lin, Z. J., Qin, L., Chen, G. Q.*, and Zhang, P*. Metabolically activated energetic materials mediate cellular anabolism for bone regeneration. Trends in Biotechnology, 2024, 42, 1745-1776. (#first author, *corresponding author)

5. Chen, F.#, Zhao, Z.#, Liu, X., Chen, H., An, L., Wang, Y., Xu, W., Guo, S., Jiang, S., Chen, G. Q., Sun, Y., Zhang, X*. A multifunctional microneedle patch loading exosomes and magnetic nanoparticles synergistically for treating oral mucosal lesions. Applied Materials Today, 2024, 40, 102382. (*corresponding author)

6. Chen, F.#, Liu, X.#, Ge, X., Wang, Y., Zhao, Z., Zhang, X.*, Chen, G. Q.*, Sun, Y. * Porous polyhydroxyalkanoates (PHA) scaffolds with antibacterial property for oral soft tissue regeneration. Chemical Engineering Journal, 2023, 451, 138899. (*corresponding author)

7. Li, J.#, Chen, J. N.#, Peng, Z. X., Chen, N. B., Liu, C. B., Zhang, P.*, Zhang, X.*, Chen, G. Q.* Multifunctional electrospinning polyhydroxyalkanoate fibrous scaffolds with antibacterial and angiogenesis effects for accelerating wound healing. ACS Applied Materials & Interfaces, 2023, 15, 364-377. (*corresponding author)

8. Hou, J.#, Zhang, X.#, Wu, Y., Jie, J., Wang, Z., Chen, G. Q.*, Sun, J.*, Wu, L. P.* Amphiphilic and fatigue-resistant organohydrogels for small-diameter vascular grafts. Science Advances, 2022, 8, eabn5360. (#first author)

9. Zhang, X.#, Li, J.#, Chen, J., Peng, Z. X., Chen, J. N., Liu, X., Wu, F., Zhang, P.*, Chen, G. Q.* Enhanced bone regeneration via PHA scaffolds coated with polydopamine-captured BMP2. Journal of Materials Chemistry B, 2022, 10, 6214-6227. (#first author)

10. Zhang, X., Li, Z., Che, X., Yu, L., Jia, W., Shen, R.,Chen, J., Ma, Y.*, Chen, G. Q*. Synthesis and characterization of polyhydroxyalkanoate organo/hydrogels. Biomacromolecules, 2019, 20, 3303-3312.